Small-molecule inhibitor cocktail promotes the proliferation of pre-existing liver progenitor cells

A recent study showed that a cocktail of three small molecules, Y-27632, A83-01, and CHIR99021 (YAC), converts mature hepatocytes (MHs) into proliferative bipotent cells that can be induced into MHs and cholangiocytes in rats. However, when we reproduced these experiments, it was found that bipotent...

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Detalles Bibliográficos
Autores principales: Fu, Qingjie, Ohnishi, Shunsuke, Suda, Goki, Sakamoto, Naoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287679/
https://www.ncbi.nlm.nih.gov/pubmed/35777357
http://dx.doi.org/10.1016/j.stemcr.2022.05.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287679/
https://www.ncbi.nlm.nih.gov/pubmed/35777357
http://dx.doi.org/10.1016/j.stemcr.2022.05.023

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