Platelet-derived growth factor (PDGF)-BB regulates the airway tone via activation of MAP2K, thromboxane, actin polymerisation and Ca(2+)-sensitisation

BACKGROUND: PDGFR-inhibition by the tyrosine kinase inhibitor (TKI) nintedanib attenuates the progress of idiopathic pulmonary fibrosis (IPF). However, the effects of PDGF-BB on the airway tone are almost unknown. We studied this issue and the mechanisms beyond, using isolated perfused lungs (IPL) o...

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Detalles Bibliográficos
Autores principales: Rieg, Annette D., Suleiman, Said, Anker, Carolin, Bünting, Nina A., Verjans, Eva, Spillner, Jan, Kalverkamp, Sebastian, von Stillfried, Saskia, Braunschweig, Till, Uhlig, Stefan, Martin, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287894/
https://www.ncbi.nlm.nih.gov/pubmed/35841089
http://dx.doi.org/10.1186/s12931-022-02101-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287894/
https://www.ncbi.nlm.nih.gov/pubmed/35841089
http://dx.doi.org/10.1186/s12931-022-02101-x

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