Selective block of sensory neuronal T-type/Cav3.2 activity mitigates neuropathic pain behavior in a rat model of osteoarthritis pain

BACKGROUND: Peripheral and central nociceptive sensitization is a critical pathogenetic component in osteoarthritis (OA) chronic pain. T-type calcium channel 3.2 (Ca(V)3.2) regulates neuronal excitability and plays important roles in pain processing. We previously identified that enhanced T-type/Ca(...

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Detalles Bibliográficos
Autores principales: Itson-Zoske, Brandon, Shin, Seung Min, Xu, Hao, Qiu, Chensheng, Fan, Fan, Hogan, Quinn H., Yu, Hongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287929/
https://www.ncbi.nlm.nih.gov/pubmed/35842727
http://dx.doi.org/10.1186/s13075-022-02856-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287929/
https://www.ncbi.nlm.nih.gov/pubmed/35842727
http://dx.doi.org/10.1186/s13075-022-02856-0

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