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A reduction of Syndecan-4 in macrophages promotes atherosclerosis by aggravating the proinflammatory capacity of macrophages

BACKGROUND: Cardiovascular diseases (CVDs) are a significant cause of mortality worldwide and are characterized by severe atherosclerosis (AS) in patients. However, the molecular mechanism of AS formation remains elusive. In the present study, we investigated the role of syndecan-4 (SDC4), a member...

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Detalles Bibliográficos
Autores principales: Hu, Jiaxin, Zhang, Ying, Hu, Liaoping, Chen, Haiting, Wu, Han, Chen, Jianzhou, Xie, Jun, Xu, Biao, Wei, Zhonghai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287986/
https://www.ncbi.nlm.nih.gov/pubmed/35842658
http://dx.doi.org/10.1186/s12967-022-03505-5