Identification of a guanine-specific pocket in the protein N of SARS-CoV-2

The SARS-CoV-2 nucleocapsid protein (N) is responsible for RNA binding. Here we report the crystal structure of the C-terminal domain (N(CTD)) in open and closed conformations and in complex with guanine triphosphate, GTP. The crystal structure and biochemical studies reveal a specific interaction b...

Descripción completa

Detalles Bibliográficos
Autores principales: Rafael Ciges-Tomas, J., Franco, María Luisa, Vilar, Marçal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288159/
https://www.ncbi.nlm.nih.gov/pubmed/35842466
http://dx.doi.org/10.1038/s42003-022-03647-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288159/
https://www.ncbi.nlm.nih.gov/pubmed/35842466
http://dx.doi.org/10.1038/s42003-022-03647-8

Ejemplares similares