Inflammasome activation in infected macrophages drives COVID-19 pathology

Severe COVID-19 is characterized by persistent lung inflammation, inflammatory cytokine production, viral RNA, and sustained interferon (IFN) response all of which are recapitulated and required for pathology in the SARS-CoV-2 infected MISTRG6-hACE2 humanized mouse model of COVID-19 with a human imm...

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Detalles Bibliográficos
Autores principales: Sefik, Esen, Qu, Rihao, Junqueira, Caroline, Kaffe, Eleanna, Mirza, Haris, Zhao, Jun, Brewer, J. Richard, Han, Ailin, Steach, Holly R., Israelow, Benjamin, Blackburn, Holly N., Velazquez, Sofia E., Chen, Y. Grace, Halene, Stephanie, Iwasaki, Akiko, Meffre, Eric, Nussenzweig, Michel, Lieberman, Judy, Wilen, Craig B., Kluger, Yuval, Flavell, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288243/
https://www.ncbi.nlm.nih.gov/pubmed/35483404
http://dx.doi.org/10.1038/s41586-022-04802-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288243/
https://www.ncbi.nlm.nih.gov/pubmed/35483404
http://dx.doi.org/10.1038/s41586-022-04802-1

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