KIT promotes tumor stroma formation and counteracts tumor-suppressive TGFβ signaling in colorectal cancer

Expression profiling has identified four consensus molecular subtypes (CMS1-4) in colorectal cancer (CRC). The receptor tyrosine kinase KIT has been associated with the most aggressive subtype, CMS4. However, it is unclear whether, and how, KIT contributes to the aggressive features of CMS4 CRC. Her...

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Detalles Bibliográficos
Autores principales: Küçükköse, Emre, Peters, Niek A., Ubink, Inge, van Keulen, Veere A. M., Daghighian, Roxanna, Verheem, André, Laoukili, Jamila, Kranenburg, Onno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288482/
https://www.ncbi.nlm.nih.gov/pubmed/35842424
http://dx.doi.org/10.1038/s41419-022-05078-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288482/
https://www.ncbi.nlm.nih.gov/pubmed/35842424
http://dx.doi.org/10.1038/s41419-022-05078-z

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