C698R mutation in Lrsam1 gene impairs nerve regeneration in a CMT2P mouse model

Missense mutation C694R in the RING domain of the LRSAM1 gene results in a dominantly inherited polyneuropathy, Charcot-Marie-Tooth disease type 2P (CMT2P). We have generated and characterized a Lrsam1(C698R) knock-in mouse model produced through CRISPR/Cas9 technology. Both heterozygous (Lrsam1(+/C...

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Detalles Bibliográficos
Autores principales: Moiseev, Daniel, Wazir, Zafar, Liu, Donghao, Li, Jun, Hu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288509/
https://www.ncbi.nlm.nih.gov/pubmed/35842440
http://dx.doi.org/10.1038/s41598-022-15902-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288509/
https://www.ncbi.nlm.nih.gov/pubmed/35842440
http://dx.doi.org/10.1038/s41598-022-15902-3

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