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C698R mutation in Lrsam1 gene impairs nerve regeneration in a CMT2P mouse model
Missense mutation C694R in the RING domain of the LRSAM1 gene results in a dominantly inherited polyneuropathy, Charcot-Marie-Tooth disease type 2P (CMT2P). We have generated and characterized a Lrsam1(C698R) knock-in mouse model produced through CRISPR/Cas9 technology. Both heterozygous (Lrsam1(+/C...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288509/ https://www.ncbi.nlm.nih.gov/pubmed/35842440 http://dx.doi.org/10.1038/s41598-022-15902-3 |