Development and characterization of a camelid derived antibody targeting a linear epitope in the hinge domain of human PCSK9 protein

PCSK9 is an effective target for lowering LDL-c. Previously, a camelid-human chimeric heavy chain antibody VHH-B11-Fc targeting human PCSK9 was designed. It had a potent hypolipidemic effect. However, the nanobody VHH-B11 interacts with PCSK9 at low affinity, while camelid VHH exhibits some immunoge...

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Detalles Bibliográficos
Autores principales: Li, Xinyang, Hong, Jun, Gao, Xiaoyan, Wang, Meiniang, Yang, Naibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288512/
https://www.ncbi.nlm.nih.gov/pubmed/35842473
http://dx.doi.org/10.1038/s41598-022-16453-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288512/
https://www.ncbi.nlm.nih.gov/pubmed/35842473
http://dx.doi.org/10.1038/s41598-022-16453-3

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