Bighorn sheep show similar in‐host responses to the same pathogen strain in two contrasting environments

Ecological context—the biotic and abiotic environment, along with its influence on population mixing dynamics and individual susceptibility—is thought to have major bearing on epidemic outcomes. However, direct comparisons of wildlife disease events in contrasting ecological contexts are often confo...

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Autores principales: Manlove, Kezia R., Roug, Annette, Sinclair, Kylie, Ricci, Lauren E., Hersey, Kent R., Martinez, Cameron, Martinez, Michael A., Mower, Kerry, Ortega, Talisa, Rominger, Eric, Ruhl, Caitlin, Tatman, Nicole, Taylor, Jace
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288933/
https://www.ncbi.nlm.nih.gov/pubmed/35866023
http://dx.doi.org/10.1002/ece3.9109
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author Manlove, Kezia R.
Roug, Annette
Sinclair, Kylie
Ricci, Lauren E.
Hersey, Kent R.
Martinez, Cameron
Martinez, Michael A.
Mower, Kerry
Ortega, Talisa
Rominger, Eric
Ruhl, Caitlin
Tatman, Nicole
Taylor, Jace
author_facet Manlove, Kezia R.
Roug, Annette
Sinclair, Kylie
Ricci, Lauren E.
Hersey, Kent R.
Martinez, Cameron
Martinez, Michael A.
Mower, Kerry
Ortega, Talisa
Rominger, Eric
Ruhl, Caitlin
Tatman, Nicole
Taylor, Jace
author_sort Manlove, Kezia R.
collection PubMed
description Ecological context—the biotic and abiotic environment, along with its influence on population mixing dynamics and individual susceptibility—is thought to have major bearing on epidemic outcomes. However, direct comparisons of wildlife disease events in contrasting ecological contexts are often confounded by concurrent differences in host genetics, exposure histories, or pathogen strains. Here, we compare disease dynamics of a Mycoplasma ovipneumoniae spillover event that affected bighorn sheep populations in two contrasting ecological contexts. One event occurred on the herd's home range near the Rio Grande Gorge in New Mexico, while the other occurred in a captive facility at Hardware Ranch in Utah. While data collection regimens varied, general patterns of antibody signal strength and symptom emergence were conserved between the two sites. Symptoms appeared in the captive setting an average of 12.9 days postexposure, average time to seroconversion was 24.9 days, and clinical signs peaked at approximately 36 days postinfection. These patterns were consistent with serological testing and subsequent declines in symptom intensity in the free‐ranging herd. At the captive site, older animals exhibited more severe declines in body condition and loin thickness, higher symptom burdens, and slower antibody response to the pathogen than younger animals. Younger animals were more likely than older animals to clear infection by the time of sampling at both sites. The patterns presented here suggest that environment may not be a major determinant of epidemiological outcomes in the bighorn sheep—M. ovipneumoniae system, elevating the possibility that host‐ or pathogen‐factors may be responsible for observed variation.
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spelling pubmed-92889332022-07-20 Bighorn sheep show similar in‐host responses to the same pathogen strain in two contrasting environments Manlove, Kezia R. Roug, Annette Sinclair, Kylie Ricci, Lauren E. Hersey, Kent R. Martinez, Cameron Martinez, Michael A. Mower, Kerry Ortega, Talisa Rominger, Eric Ruhl, Caitlin Tatman, Nicole Taylor, Jace Ecol Evol Nature Notes Ecological context—the biotic and abiotic environment, along with its influence on population mixing dynamics and individual susceptibility—is thought to have major bearing on epidemic outcomes. However, direct comparisons of wildlife disease events in contrasting ecological contexts are often confounded by concurrent differences in host genetics, exposure histories, or pathogen strains. Here, we compare disease dynamics of a Mycoplasma ovipneumoniae spillover event that affected bighorn sheep populations in two contrasting ecological contexts. One event occurred on the herd's home range near the Rio Grande Gorge in New Mexico, while the other occurred in a captive facility at Hardware Ranch in Utah. While data collection regimens varied, general patterns of antibody signal strength and symptom emergence were conserved between the two sites. Symptoms appeared in the captive setting an average of 12.9 days postexposure, average time to seroconversion was 24.9 days, and clinical signs peaked at approximately 36 days postinfection. These patterns were consistent with serological testing and subsequent declines in symptom intensity in the free‐ranging herd. At the captive site, older animals exhibited more severe declines in body condition and loin thickness, higher symptom burdens, and slower antibody response to the pathogen than younger animals. Younger animals were more likely than older animals to clear infection by the time of sampling at both sites. The patterns presented here suggest that environment may not be a major determinant of epidemiological outcomes in the bighorn sheep—M. ovipneumoniae system, elevating the possibility that host‐ or pathogen‐factors may be responsible for observed variation. John Wiley and Sons Inc. 2022-07-17 /pmc/articles/PMC9288933/ /pubmed/35866023 http://dx.doi.org/10.1002/ece3.9109 Text en © 2022 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Nature Notes
Manlove, Kezia R.
Roug, Annette
Sinclair, Kylie
Ricci, Lauren E.
Hersey, Kent R.
Martinez, Cameron
Martinez, Michael A.
Mower, Kerry
Ortega, Talisa
Rominger, Eric
Ruhl, Caitlin
Tatman, Nicole
Taylor, Jace
Bighorn sheep show similar in‐host responses to the same pathogen strain in two contrasting environments
title Bighorn sheep show similar in‐host responses to the same pathogen strain in two contrasting environments
title_full Bighorn sheep show similar in‐host responses to the same pathogen strain in two contrasting environments
title_fullStr Bighorn sheep show similar in‐host responses to the same pathogen strain in two contrasting environments
title_full_unstemmed Bighorn sheep show similar in‐host responses to the same pathogen strain in two contrasting environments
title_short Bighorn sheep show similar in‐host responses to the same pathogen strain in two contrasting environments
title_sort bighorn sheep show similar in‐host responses to the same pathogen strain in two contrasting environments
topic Nature Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288933/
https://www.ncbi.nlm.nih.gov/pubmed/35866023
http://dx.doi.org/10.1002/ece3.9109
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