CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers

Chimeric antigen receptor T cells (CAR T cells) are effective against haematologic malignancies. However, in solid tumours, their potency is hampered by local immunosuppression and by the heterogeneous expression of the antigen that the CAR targets. Here we show that CAR T cells expressing a pluripo...

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Detalles Bibliográficos
Autores principales: Jin, Chuan, Ma, Jing, Ramachandran, Mohanraj, Yu, Di, Essand, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288934/
https://www.ncbi.nlm.nih.gov/pubmed/35379957
http://dx.doi.org/10.1038/s41551-022-00875-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288934/
https://www.ncbi.nlm.nih.gov/pubmed/35379957
http://dx.doi.org/10.1038/s41551-022-00875-5

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