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CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers
Chimeric antigen receptor T cells (CAR T cells) are effective against haematologic malignancies. However, in solid tumours, their potency is hampered by local immunosuppression and by the heterogeneous expression of the antigen that the CAR targets. Here we show that CAR T cells expressing a pluripo...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288934/ https://www.ncbi.nlm.nih.gov/pubmed/35379957 http://dx.doi.org/10.1038/s41551-022-00875-5 |