Accelerating PERx reaction enables covalent nanobodies for potent neutralization of SARS-CoV-2 and variants

The long-lasting COVID-19 pandemic and increasing SARS-CoV-2 variants demand effective drugs for prophylactics and treatment. Protein-based biologics offer high specificity, yet their noncovalent interactions often lead to drug dissociation and incomplete inhibition. Here, we have developed covalent...

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Detalles Bibliográficos
Autores principales: Yu, Bingchen, Li, Shanshan, Tabata, Takako, Wang, Nanxi, Cao, Li, Kumar, G. Renuka, Sun, Wei, Liu, Jun, Ott, Melanie, Wang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288967/
https://www.ncbi.nlm.nih.gov/pubmed/35874165
http://dx.doi.org/10.1016/j.chempr.2022.07.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288967/
https://www.ncbi.nlm.nih.gov/pubmed/35874165
http://dx.doi.org/10.1016/j.chempr.2022.07.012

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