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Accelerating PERx reaction enables covalent nanobodies for potent neutralization of SARS-CoV-2 and variants
The long-lasting COVID-19 pandemic and increasing SARS-CoV-2 variants demand effective drugs for prophylactics and treatment. Protein-based biologics offer high specificity, yet their noncovalent interactions often lead to drug dissociation and incomplete inhibition. Here, we have developed covalent...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288967/ https://www.ncbi.nlm.nih.gov/pubmed/35874165 http://dx.doi.org/10.1016/j.chempr.2022.07.012 |