RAD21 Confers Poor Prognosis and Affects Ovarian Cancer Sensitivity to Poly(ADP-Ribose)Polymerase Inhibitors Through DNA Damage Repair

BACKGROUND: Poly(ADP-ribose)polymerase (PARP) inhibitors are a class of molecular-targeted cancer drugs. Synthetic lethality is a phenomenon that renders homologous recombination repair defective cells more sensitive to PARP inhibitors. As a component of the cohesin complex, RAD21 regulates DNA dama...

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Detalles Bibliográficos
Autores principales: Gou, Rui, Li, Xiao, Dong, Hui, Hu, Yuexin, Liu, Ouxuan, Liu, Juanjuan, Lin, Bei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289200/
https://www.ncbi.nlm.nih.gov/pubmed/35860572
http://dx.doi.org/10.3389/fonc.2022.936550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289200/
https://www.ncbi.nlm.nih.gov/pubmed/35860572
http://dx.doi.org/10.3389/fonc.2022.936550

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