Targeting DNA-Protein Crosslinks via Post-Translational Modifications

Covalent binding of proteins to DNA forms DNA-protein crosslinks (DPCs), which represent cytotoxic DNA lesions that interfere with essential processes such as DNA replication and transcription. Cells possess different enzymatic activities to counteract DPCs. These include enzymes that degrade the ad...

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Detalles Bibliográficos
Autores principales: Leng, Xueyuan, Duxin, Julien P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289515/
https://www.ncbi.nlm.nih.gov/pubmed/35860355
http://dx.doi.org/10.3389/fmolb.2022.944775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289515/
https://www.ncbi.nlm.nih.gov/pubmed/35860355
http://dx.doi.org/10.3389/fmolb.2022.944775

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