Innovative Approach for a Classic Target: Fragment Screening on Trypanothione Reductase Reveals New Opportunities for Drug Design

Trypanothione reductase (TR) is a key factor in the redox homeostasis of trypanosomatid parasites, critical for survival in the hostile oxidative environment generated by the host to fight infection. TR is considered an attractive target for the development of new trypanocidal agents as it is essent...

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Detalles Bibliográficos
Autores principales: Fiorillo, Annarita, Colotti, Gianni, Exertier, Cécile, Liuzzi, Anastasia, Seghetti, Francesca, Salerno, Alessandra, Caciolla, Jessica, Ilari, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289546/
https://www.ncbi.nlm.nih.gov/pubmed/35860359
http://dx.doi.org/10.3389/fmolb.2022.900882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289546/
https://www.ncbi.nlm.nih.gov/pubmed/35860359
http://dx.doi.org/10.3389/fmolb.2022.900882

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