Chemogenetic profiling reveals PP2A‐independent cytotoxicity of proposed PP2A activators iHAP1 and DT‐061

Protein phosphatase 2A (PP2A) is an abundant phosphoprotein phosphatase that acts as a tumor suppressor. For this reason, compounds able to activate PP2A are attractive anticancer agents. The compounds iHAP1 and DT‐061 have recently been reported to selectively stabilize specific PP2A‐B56 complexes...

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Detalles Bibliográficos
Autores principales: Vit, Gianmatteo, Duro, Joana, Rajendraprasad, Girish, Hertz, Emil P T, Holland, Lya Katrine Kauffeldt, Weisser, Melanie Bianca, McEwan, Brennan C, Lopez‐Mendez, Blanca, Sotelo‐Parrilla, Paula, Jeyaprakash, A Arockia, Montoya, Guillermo, Mailand, Niels, Maeda, Kenji, Kettenbach, Arminja, Barisic, Marin, Nilsson, Jakob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289710/
https://www.ncbi.nlm.nih.gov/pubmed/35695070
http://dx.doi.org/10.15252/embj.2022110611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289710/
https://www.ncbi.nlm.nih.gov/pubmed/35695070
http://dx.doi.org/10.15252/embj.2022110611

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