Neutrophil Elastase-Activatable Prodrugs Based on an Alkoxyamine Platform to Deliver Alkyl Radicals Cytotoxic to Tumor Cells

[Image: see text] Current chemotherapies suffer low specificity and sometimes drug resistance. Neutrophil elastase activity in cancer is associated with poor prognosis and metastasis settlement. More generally, tumors harbor various and persistent protease activities unseen in healthy tissues. In an...

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Detalles Bibliográficos
Autores principales: Seren, Seda, Joly, Jean-Patrick, Voisin, Pierre, Bouchaud, Véronique, Audran, Gérard, Marque, Sylvain R. A., Mellet, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289877/
https://www.ncbi.nlm.nih.gov/pubmed/35764297
http://dx.doi.org/10.1021/acs.jmedchem.2c00455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289877/
https://www.ncbi.nlm.nih.gov/pubmed/35764297
http://dx.doi.org/10.1021/acs.jmedchem.2c00455

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