Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters

[Image: see text] Here, we report on a potent class of substituted ureidothiophenes targeting energy-coupling factor (ECF) transporters, an unexplored target that is not addressed by any antibiotic in the market. Since the ECF module is crucial for the vitamin transport mechanism, the prevention of...

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Detalles Bibliográficos
Autores principales: Kiefer, Alexander F., Bousis, Spyridon, Hamed, Mostafa M., Diamanti, Eleonora, Haupenthal, Jörg, Hirsch, Anna K.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289886/
https://www.ncbi.nlm.nih.gov/pubmed/35709475
http://dx.doi.org/10.1021/acs.jmedchem.1c02114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289886/
https://www.ncbi.nlm.nih.gov/pubmed/35709475
http://dx.doi.org/10.1021/acs.jmedchem.1c02114

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