Development of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain

[Image: see text] Human African Trypanosomiasis (HAT) is a neglected tropical disease widespread in sub-Saharan Africa. Rhodesain, a cysteine protease of Trypanosoma brucei rhodesiense, has been identified as a valid target for the development of anti-HAT agents. Herein, we report a series of urea-b...

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Detalles Bibliográficos
Autores principales: Previti, Santo, Ettari, Roberta, Calcaterra, Elsa, Di Chio, Carla, Ravichandran, Rahul, Zimmer, Collin, Hammerschmidt, Stefan, Wagner, Annika, Bogacz, Marta, Cosconati, Sandro, Schirmeister, Tanja, Zappalà, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290002/
https://www.ncbi.nlm.nih.gov/pubmed/35859868
http://dx.doi.org/10.1021/acsmedchemlett.2c00084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290002/
https://www.ncbi.nlm.nih.gov/pubmed/35859868
http://dx.doi.org/10.1021/acsmedchemlett.2c00084

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