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Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na(+)/H(+) Exchanger Isoform 3
[Image: see text] We present herein the design, synthesis, and optimization of gut-restricted inhibitors of Na(+)/H(+) exchanger isoform 3 (NHE3). NHE3 is predominantly expressed in the kidney and gastrointestinal tract where it acts as the major absorptive sodium transporter. We desired minimally s...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290029/ https://www.ncbi.nlm.nih.gov/pubmed/35859876 http://dx.doi.org/10.1021/acsmedchemlett.2c00037 |