Optimization of the production process for the anticancer lead compound illudin M: process development in stirred tank bioreactors

BACKGROUND: The fungal natural products illudin S and M have been investigated as precursors for the development of semisynthetic anticancer agents such as Irofulven (illudin S derivative) which is currently in phase II clinical trials. Recently, illudin M derivatives have shown improved in vitro se...

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Detalles Bibliográficos
Autores principales: Chaverra-Muñoz, Lillibeth, Hüttel, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290264/
https://www.ncbi.nlm.nih.gov/pubmed/35843931
http://dx.doi.org/10.1186/s12934-022-01870-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290264/
https://www.ncbi.nlm.nih.gov/pubmed/35843931
http://dx.doi.org/10.1186/s12934-022-01870-w

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