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Optimization of the production process for the anticancer lead compound illudin M: process development in stirred tank bioreactors
BACKGROUND: The fungal natural products illudin S and M have been investigated as precursors for the development of semisynthetic anticancer agents such as Irofulven (illudin S derivative) which is currently in phase II clinical trials. Recently, illudin M derivatives have shown improved in vitro se...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290264/ https://www.ncbi.nlm.nih.gov/pubmed/35843931 http://dx.doi.org/10.1186/s12934-022-01870-w |