Pre‐clinical evaluation of dual targeting of the GPCRs CaSR and V2R as therapeutic strategy for autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations of PKD1 or PKD2 genes, is characterized by development and growth of cysts causing progressive kidney enlargement. Reduced resting cytosolic calcium and increased cAMP levels associated with the tonic action of vasopressin are...

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Detalles Bibliográficos
Autores principales: Di Mise, Annarita, Wang, Xiaofang, Ye, Hong, Pellegrini, Lorenzo, Torres, Vicente E., Valenti, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290345/
https://www.ncbi.nlm.nih.gov/pubmed/34486176
http://dx.doi.org/10.1096/fj.202100774R

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290345/
https://www.ncbi.nlm.nih.gov/pubmed/34486176
http://dx.doi.org/10.1096/fj.202100774R

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