Recognition of the TDP-43 nuclear localization signal by importin α1/β

Cytoplasmic mislocalization of the TAR-DNA binding protein of 43 kDa (TDP-43) leads to large, insoluble aggregates that are a hallmark of amyotrophic lateral sclerosis and frontotemporal dementia. Here, we study how importin α1/β recognizes TDP-43 bipartite nuclear localization signal (NLS). We find...

Descripción completa

Detalles Bibliográficos
Autores principales: Doll, Steven G., Meshkin, Hamed, Bryer, Alexander J., Li, Fenglin, Ko, Ying-Hui, Lokareddy, Ravi K., Gillilan, Richard E., Gupta, Kushol, Perilla, Juan R., Cingolani, Gino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290431/
https://www.ncbi.nlm.nih.gov/pubmed/35767952
http://dx.doi.org/10.1016/j.celrep.2022.111007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290431/
https://www.ncbi.nlm.nih.gov/pubmed/35767952
http://dx.doi.org/10.1016/j.celrep.2022.111007

Ejemplares similares