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Recognition of the TDP-43 nuclear localization signal by importin α1/β

Cytoplasmic mislocalization of the TAR-DNA binding protein of 43 kDa (TDP-43) leads to large, insoluble aggregates that are a hallmark of amyotrophic lateral sclerosis and frontotemporal dementia. Here, we study how importin α1/β recognizes TDP-43 bipartite nuclear localization signal (NLS). We find...

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Detalles Bibliográficos
Autores principales:	Doll, Steven G., Meshkin, Hamed, Bryer, Alexander J., Li, Fenglin, Ko, Ying-Hui, Lokareddy, Ravi K., Gillilan, Richard E., Gupta, Kushol, Perilla, Juan R., Cingolani, Gino
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290431/ https://www.ncbi.nlm.nih.gov/pubmed/35767952 http://dx.doi.org/10.1016/j.celrep.2022.111007

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