Rh(II)‐Catalyzed De‐symmetrization of Ethane‐1,2‐dithiol and Propane‐1,3‐dithiol Yields Metallo‐β‐lactamase Inhibitors

Diversity‐oriented synthesis (DOS) is a rich source for novel lead structures in Medicinal Chemistry. In this study, we present a DOS‐compatible method for synthesis of compounds bearing a free thiol moiety. The procedure relies on Rh(II)‐catalyzed coupling of dithiols to diazo building blocks. The...

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Detalles Bibliográficos
Autores principales: Krasavin, Mikhail, Zhukovsky, Daniil, Solovyev, Igor, Barkhatova, Darina, Dar'in, Dmitry, Frank, Denia, Martinelli, Giada, Weizel, Lilia, Proschak, Anna, Rotter, Marco, Kramer, Jan S., Brunst, Steffen, Wichelhaus, Thomas A., Proschak, Ewgenij
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290507/
https://www.ncbi.nlm.nih.gov/pubmed/34184833
http://dx.doi.org/10.1002/cmdc.202100344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290507/
https://www.ncbi.nlm.nih.gov/pubmed/34184833
http://dx.doi.org/10.1002/cmdc.202100344

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