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Assessment of cellular and molecular metrics for dose selection in an in vivo comet assay: A case study with MDI

The in vivo comet assay can evaluate the genotoxic potential of a chemical in theoretically any tissue that can be processed to a single cell suspension. This flexibility enables evaluation of point‐of‐contact tissues using a relevant route of test material administration; however, assessing cytotox...

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Detalles Bibliográficos
Autores principales: Ji, Zhiying, Koehler, Matthew W., Scott, Andrew B., LeBaron, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290646/
https://www.ncbi.nlm.nih.gov/pubmed/34369617
http://dx.doi.org/10.1002/em.22457