Physiologically based pharmacokinetic modelling of treprostinil after intravenous injection and extended‐release oral tablet administration in healthy volunteers: An extrapolation to other patient populations including patients with hepatic impairment

AIMS: Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary arterial pressure, resulting in right ventricular overload, right heart failure and eventually death. Treprostinil is a prostacyclin analogue that is used in the treatment of PAH. As an orphan drug, limited informati...

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Detalles Bibliográficos
Autores principales: Wu, Xuemei, Zhang, Xiaohan, Xu, Ruichao, Shaik, Imam Hussain, Venkataramanan, Raman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290939/
https://www.ncbi.nlm.nih.gov/pubmed/34190364
http://dx.doi.org/10.1111/bcp.14966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9290939/
https://www.ncbi.nlm.nih.gov/pubmed/34190364
http://dx.doi.org/10.1111/bcp.14966

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