Safety, pharmacokinetics and quantitative EEG modulation of TAK‐071, a novel muscarinic M1 receptor positive allosteric modulator, in healthy subjects

AIMS: TAK‐071 is a muscarinic M(1) receptor positive allosteric modulator designed to have low cooperativity with acetylcholine. This was a first‐in‐human study to evaluate the safety, pharmacokinetics, and pharmacodynamics of TAK‐071. METHODS: TAK‐071 was administered as single and multiple doses i...

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Detalles Bibliográficos
Autores principales: Yin, Wei, Mamashli, Fahimeh, Buhl, Derek L., Khudyakov, Polyna, Volfson, Dmitri, Martenyi, Ferenc, Gevorkyan, Hakop, Rosen, Laura, Simen, Arthur A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291057/
https://www.ncbi.nlm.nih.gov/pubmed/34240455
http://dx.doi.org/10.1111/bcp.14975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291057/
https://www.ncbi.nlm.nih.gov/pubmed/34240455
http://dx.doi.org/10.1111/bcp.14975

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