Self-Masked Aldehyde Inhibitors of Human Cathepsin L Are Potent Anti-CoV-2 Agents

Cysteine proteases comprise an important class of drug targets, especially for infectious diseases such as Chagas disease (cruzain) and COVID-19 (3CL protease, cathepsin L). Peptide aldehydes have proven to be potent inhibitors for all of these proteases. However, the intrinsic, high electrophilicit...

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Detalles Bibliográficos
Autores principales: Zhu, Jiyun, Li, Linfeng, Drelich, Aleksandra, Chenna, Bala C., Mellott, Drake M., Taylor, Zane W., Tat, Vivian, Garcia, Christopher Z., Katzfuss, Ardala, Tseng, Chien-Te K., Meek, Thomas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291521/
https://www.ncbi.nlm.nih.gov/pubmed/35860632
http://dx.doi.org/10.3389/fchem.2022.867928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291521/
https://www.ncbi.nlm.nih.gov/pubmed/35860632
http://dx.doi.org/10.3389/fchem.2022.867928

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