Structural basis for Dicer-like function of an engineered RNase III variant and insights into the reaction trajectory of two-Mg(2+)-ion catalysis

The RNase III family of dsRNA-specific endonucleases is exemplified by prokaryotic RNase III and eukaryotic Rnt1p, Drosha, and Dicer. Structures of Aquifex aeolicus RNase III (AaRNase III) and Saccharomyces cerevisiae Rnt1p (ScRnt1p) show that both enzymes recognize substrates in a sequence-specific...

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Detalles Bibliográficos
Autores principales: Dharavath, Sudhaker, Shaw, Gary X., Ji, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291653/
https://www.ncbi.nlm.nih.gov/pubmed/35829618
http://dx.doi.org/10.1080/15476286.2022.2099650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291653/
https://www.ncbi.nlm.nih.gov/pubmed/35829618
http://dx.doi.org/10.1080/15476286.2022.2099650

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