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Structural basis for Dicer-like function of an engineered RNase III variant and insights into the reaction trajectory of two-Mg(2+)-ion catalysis
The RNase III family of dsRNA-specific endonucleases is exemplified by prokaryotic RNase III and eukaryotic Rnt1p, Drosha, and Dicer. Structures of Aquifex aeolicus RNase III (AaRNase III) and Saccharomyces cerevisiae Rnt1p (ScRnt1p) show that both enzymes recognize substrates in a sequence-specific...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291653/ https://www.ncbi.nlm.nih.gov/pubmed/35829618 http://dx.doi.org/10.1080/15476286.2022.2099650 |