Design, synthesis, and anti-cancer evaluation of new pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as potential EGFRWT and EGFRT790M inhibitors and apoptosis inducers

A new series of pyrido[2,3-d]pyrimidin-4(3H)-one derivatives having the essential pharmacophoric features of EGFR inhibitors has been designed and synthesised. Cell viability screening was performed for these compounds against A-549, PC-3, HCT-116, and MCF-7 cell lines at a dose of 100 μM. The highe...

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Detalles Bibliográficos
Autores principales: Elzahabi, Heba S. A., Nossier, Eman S., Alasfoury, Rania A., El-Manawaty, May, Sayed, Sara M., Elkaeed, Eslam B., Metwaly, Ahmed M., Hagras, Mohamed, Eissa, Ibrahim H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291687/
https://www.ncbi.nlm.nih.gov/pubmed/35821615
http://dx.doi.org/10.1080/14756366.2022.2062752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291687/
https://www.ncbi.nlm.nih.gov/pubmed/35821615
http://dx.doi.org/10.1080/14756366.2022.2062752

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