Zap‐Pano: a Photocaged Prodrug of the KDAC Inhibitor Panobinostat

We report the synthesis and biological evaluation of a light‐activated (caged) prodrug of the KDAC inhibitor panobinostat (Zap‐Pano). We demonstrate that addition of the 4,5‐dimethoxy‐2‐nitrobenzyl group to the hydroxamic acid oxygen results in an inactive prodrug. In two cancer cell lines we show t...

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Detalles Bibliográficos
Autores principales: Troelsen, Kathrin S., Calder, Ewen D. D., Skwarska, Anna, Sneddon, Deborah, Hammond, Ester M., Conway, Stuart J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291796/
https://www.ncbi.nlm.nih.gov/pubmed/34259396
http://dx.doi.org/10.1002/cmdc.202100403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291796/
https://www.ncbi.nlm.nih.gov/pubmed/34259396
http://dx.doi.org/10.1002/cmdc.202100403

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