Evaluation of the drug‐drug interaction potential of treosulfan using a physiologically‐based pharmacokinetic modelling approach

AIMS: The aim of this work is the development of a mechanistic physiologically‐based pharmacokinetic (PBPK) model using in vitro to in vivo extrapolation to conduct a drug‐drug interaction (DDI) assessment of treosulfan against two cytochrome p450 (CYP) isoenzymes and P‐glycoprotein (P‐gp) substrate...

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Detalles Bibliográficos
Autores principales: Schaller, Stephan, Martins, Frederico S., Balazki, Pavel, Böhm, Sonja, Baumgart, Joachim, Hilger, Ralf A., Beelen, Dietrich W., Hemmelmann, Claudia, Ring, Arne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291915/
https://www.ncbi.nlm.nih.gov/pubmed/34519068
http://dx.doi.org/10.1111/bcp.15081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9291915/
https://www.ncbi.nlm.nih.gov/pubmed/34519068
http://dx.doi.org/10.1111/bcp.15081

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