Bayesian dose regimen assessment in early phase oncology incorporating pharmacokinetics and pharmacodynamics

Phase I dose‐finding trials in oncology seek to find the maximum tolerated dose of a drug under a specific schedule. Evaluating drug schedules aims at improving treatment safety while maintaining efficacy. However, while we can reasonably assume that toxicity increases with the dose for cytotoxic dr...

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Detalles Bibliográficos
Autores principales: Gerard, Emma, Zohar, Sarah, Thai, Hoai‐Thu, Lorenzato, Christelle, Riviere, Marie‐Karelle, Ursino, Moreno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Biometric Practice
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292001/
https://www.ncbi.nlm.nih.gov/pubmed/33527351
http://dx.doi.org/10.1111/biom.13433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292001/
https://www.ncbi.nlm.nih.gov/pubmed/33527351
http://dx.doi.org/10.1111/biom.13433

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