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Bayesian dose regimen assessment in early phase oncology incorporating pharmacokinetics and pharmacodynamics
Phase I dose‐finding trials in oncology seek to find the maximum tolerated dose of a drug under a specific schedule. Evaluating drug schedules aims at improving treatment safety while maintaining efficacy. However, while we can reasonably assume that toxicity increases with the dose for cytotoxic dr...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292001/ https://www.ncbi.nlm.nih.gov/pubmed/33527351 http://dx.doi.org/10.1111/biom.13433 |