Cargando…
In vivo Treg expansion under costimulation blockade targets early rejection and improves long‐term outcome
CTLA4Ig has been shown to improve kidney allograft function, but an increased frequency of early rejection episodes poses a major obstacle for more widespread clinical use. The deleterious effect of CTLA4Ig on Treg numbers provides a possible explanation for graft injury. Therefore, we aimed at impr...
Autores principales: | Schwarz, Christoph, Mahr, Benedikt, Muckenhuber, Moritz, Weijler, Anna Marianne, Unger, Lukas Walter, Pilat, Nina, Latus, Michaela, Regele, Heinz, Wekerle, Thomas |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292010/ https://www.ncbi.nlm.nih.gov/pubmed/34152692 http://dx.doi.org/10.1111/ajt.16724 |
Ejemplares similares
-
Costimulation blockade and Tregs in solid organ transplantation
por: Muckenhuber, Moritz, et al.
Publicado: (2022) -
Chronic CD40L blockade is required for long-term cardiac allograft survival with a clinically relevant CTLA4-Ig dosing regimen
por: Unger, Lukas W., et al.
Publicado: (2022) -
Distinct roles for major and minor antigen barriers in chimerism‐based tolerance under irradiation‐free conditions
por: Mahr, Benedikt, et al.
Publicado: (2020) -
Anti-Interleukin-6 Promotes Allogeneic Bone Marrow Engraftment and Prolonged Graft Survival in an Irradiation-Free Murine Transplant Model
por: Granofszky, Nicolas, et al.
Publicado: (2017) -
Minor Antigen Disparities Impede Induction of Long Lasting Chimerism and Tolerance through Bone Marrow Transplantation with Costimulation Blockade
por: Bigenzahn, Sinda, et al.
Publicado: (2016)