Pharmacokinetics and Metabolism of Ziritaxestat (GLPG1690) in Healthy Male Volunteers Following Intravenous and Oral Administration

Ziritaxestat is a novel inhibitor of autotaxin, an enzyme responsible for the production of lysophosphatidic acid, the downstream signaling of which mediates responses to tissue injury and has been implicated in the pathogenesis of fibrotic conditions such as idiopathic pulmonary fibrosis and system...

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Detalles Bibliográficos
Autores principales: Helmer, Eric, Willson, Ashley, Brearley, Christopher, Westerhof, Mark, Delage, Stephane, Shaw, Iain, Cooke, Ray, Sidhu, Sharan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292235/
https://www.ncbi.nlm.nih.gov/pubmed/34633152
http://dx.doi.org/10.1002/cpdd.1021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292235/
https://www.ncbi.nlm.nih.gov/pubmed/34633152
http://dx.doi.org/10.1002/cpdd.1021

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