Janus All‐Cis 2,3,4,5,6‐Pentafluorocyclohexyl Building Blocks Applied to Medicinal Chemistry and Bioactives Discovery Chemistry

Monoalkylated derivatives of the unusually polar all‐cis 2,3,4,5,6‐ pentafluorocyclohexyl (Janus face) motif are prepared starting from an aryl hydrogenation of 2,3,4,5,6‐ pentafluorophenylacetate methyl ester 15. The method used Zeng's Rh(CAAC) carbene catalyst 4 in the hydrogenation following...

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Detalles Bibliográficos
Autores principales: Clark, Joshua L., Neyyappadath, Rifahath M., Yu, Cihang, Slawin, Alexandra M. Z., Cordes, David B., O'Hagan, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292521/
https://www.ncbi.nlm.nih.gov/pubmed/34486192
http://dx.doi.org/10.1002/chem.202102819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292521/
https://www.ncbi.nlm.nih.gov/pubmed/34486192
http://dx.doi.org/10.1002/chem.202102819

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