Protein Design with Fluoroprolines: 4,4‐Difluoroproline Does Not Eliminate the Rate‐Limiting Step of Thioredoxin Folding

C(4)‐substituted fluoroprolines (4R)‐fluoroproline ((4R)‐Flp) and (4S)‐fluoroproline ((4S)‐Flp) have been used in protein engineering to enhance the thermodynamic stability of peptides and proteins. The electron‐withdrawing effect of fluorine can bias the pucker of the pyrrolidine ring, influence th...

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Detalles Bibliográficos
Autores principales: O' Loughlin, Jennie, Napolitano, Silvia, Rubini, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292674/
https://www.ncbi.nlm.nih.gov/pubmed/34545985
http://dx.doi.org/10.1002/cbic.202100418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292674/
https://www.ncbi.nlm.nih.gov/pubmed/34545985
http://dx.doi.org/10.1002/cbic.202100418

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