Cargando…

Protein Design with Fluoroprolines: 4,4‐Difluoroproline Does Not Eliminate the Rate‐Limiting Step of Thioredoxin Folding

C(4)‐substituted fluoroprolines (4R)‐fluoroproline ((4R)‐Flp) and (4S)‐fluoroproline ((4S)‐Flp) have been used in protein engineering to enhance the thermodynamic stability of peptides and proteins. The electron‐withdrawing effect of fluorine can bias the pucker of the pyrrolidine ring, influence th...

Descripción completa

Detalles Bibliográficos
Autores principales:	O' Loughlin, Jennie, Napolitano, Silvia, Rubini, Marina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292674/ https://www.ncbi.nlm.nih.gov/pubmed/34545985 http://dx.doi.org/10.1002/cbic.202100418

Ejemplares similares

Rational Design of Protein Stability: Effect of (2S,4R)-4-Fluoroproline on the Stability and Folding Pathway of Ubiquitin
por: Crespo, Maria D., et al.
Publicado: (2011)

Synthetic Biology of Proteins: Tuning GFPs Folding and Stability with Fluoroproline
por: Steiner, Thomas, et al.
Publicado: (2008)

Biochemistry of fluoroprolines: the prospect of making fluorine a bioelement
por: Kubyshkin, Vladimir, et al.
Publicado: (2021)

Fluorine NMR study of proline-rich sequences using fluoroprolines
por: Sinnaeve, Davy, et al.
Publicado: (2021)

Trojan Horse Delivery of 4,4′‐Dimethoxychalcone for Parkinsonian Neuroprotection
por: Zhang, Wenlong, et al.
Publicado: (2021)

Functional analyses of ancestral thioredoxins provide insights into their evolutionary history
por: Napolitano, Silvia, et al.
Publicado: (2019)

Microphotochemistry: 4,4'-Dimethoxybenzophenone mediated photodecarboxylation reactions involving phthalimides
por: Shvydkiv, Oksana, et al.
Publicado: (2011)

Glutathione Transferases Are Structural and Functional Outliers in the Thioredoxin Fold
por: Atkinson, Holly J., et al.
Publicado: (2009)

Complexation of 2,6-helic[6]arene and its derivatives with 1,1′-dimethyl-4,4′-bipyridinium salts and protonated 4,4'-bipyridinium salts: an acid–base controllable complexation
por: Li, Jing, et al.
Publicado: (2019)

Non-conservation of folding rates in the thioredoxin family reveals degradation of ancestral unassisted-folding
por: Gamiz-Arco, Gloria, et al.
Publicado: (2019)

Heavy atom effects in the Paternò–Büchi reaction of pyrimidine derivatives with 4,4’-disubstituted benzophenones
por: Kong, Feng-Feng, et al.
Publicado: (2011)

An unusual thionyl chloride-promoted C−C bond formation to obtain 4,4'-bipyrazolones
por: Eller, Gernot A, et al.
Publicado: (2018)

Effect of Signal Peptide on Stability and Folding of Escherichia coli Thioredoxin
por: Singh, Pranveer, et al.
Publicado: (2013)

An Extended Active-site Motif Controls the Reactivity of the Thioredoxin Fold
por: Mavridou, Despoina A. I., et al.
Publicado: (2014)

Synthesis and Electrochemical and Photophysical Characterization of New 4,4′‐π‐Conjugated 2,2′‐Bipyridines that are End‐Capped with Cyanoacrylic Acid/Ester Groups
por: Fingerhut, Anja, et al.
Publicado: (2016)

Double N-arylation reaction of polyhalogenated 4,4’-bipyridines. Expedious synthesis of functionalized 2,7-diazacarbazoles
por: Abboud, Mohamed, et al.
Publicado: (2012)

Synthesis of 1-azaspiro[4.4]nonan-1-oxyls via intramolecular 1,3-dipolar cycloaddition
por: Khoroshunova, Yulia V, et al.
Publicado: (2019)

An Atlas of the Thioredoxin Fold Class Reveals the Complexity of Function-Enabling Adaptations
por: Atkinson, Holly J., et al.
Publicado: (2009)

A refined method for analysis of 4,4′-dicofol and 4,4′-dichlorobenzophenone
por: Yin, Ge, et al.
Publicado: (2017)

Asymmetric Synthesis of 4,4‐(Difluoro)glutamic Acid via Chiral Ni(II)‐Complexes of Dehydroalanine Schiff Bases. Effect of the Chiral Ligands Structure on the Stereochemical Outcome
por: Tokairin, Yoshinori, et al.
Publicado: (2020)

Properties of the Thioredoxin Fold Superfamily Are Modulated by a Single Amino Acid Residue
por: Ren, Guoping, et al.
Publicado: (2009)

Reactions of N,3-diarylpropiolamides with arenes under superelectrophilic activation: synthesis of 4,4-diaryl-3,4-dihydroquinolin-2(1H)-ones and their derivatives
por: Gurskaya, Larisa Yu, et al.
Publicado: (2016)

Role of thioredoxin-interacting protein in mediating endothelial dysfunction in hypertension
por: Wang, Ruiyu, et al.
Publicado: (2020)

Multi-step Redox Systems with NIR-Fluorescence Based on 4H-Imidazoles
por: Matschke, Martin, et al.
Publicado: (2007)

Genotoxicological Characterization of (±)cis-4,4′-DMAR and (±)trans-4,4′-DMAR and Their Association
por: Lenzi, Monia, et al.
Publicado: (2022)

Sensitization and cross‐reactivity patterns of contact allergy to diisocyanates and corresponding amines: investigation of diphenylmethane‐4,4′‐diisocyanate, diphenylmethane‐4,4′‐diamine, dicyclohexylmethane‐4,4′‐diisocyanate, and dicylohexylmethane‐4,4′‐diamine
por: Hamada, Haneen, et al.
Publicado: (2017)

SbCl(3)-catalyzed one-pot synthesis of 4,4′-diaminotriarylmethanes under solvent-free conditions: Synthesis, characterization, and DFT studies
por: Bardajee, Ghasem Rezanejade
Publicado: (2011)

Transmetallation Versus β-Hydride Elimination: The Role of 1,4-Benzoquinone in Chelation-Controlled Arylation Reactions with Arylboronic Acids
por: Sköld, Christian, et al.
Publicado: (2012)

Disodium 4,4′-oxydibenzoate
por: Yang, Yuan, et al.
Publicado: (2008)

4,4′-Azinodibenzoic acid
por: Yu, Qun-Di, et al.
Publicado: (2009)

Flips for 3-folds and 4-folds
por: Corti, Alessio
Publicado: (2007)

Deciphering the Role of Multiple Thioredoxin Fold Proteins of Leptospirillum sp. in Oxidative Stress Tolerance
por: González, Daniela, et al.
Publicado: (2020)

Bis(4,4′-bipyridinium) dodecatungstosilicate 4,4′-bipyridine hexahydrate
por: Ma, Feng-Xia, et al.
Publicado: (2008)

4,4′-[4,4′-Sulfonylbis(p-phenyleneoxy)]dibutanoic acid
por: Fu, Chun-Yan, et al.
Publicado: (2011)

Crystal structure of 4,4′-(disulfanediyl)dibutanoic acid–4,4′-bipyridine (1/1)
por: Atria, Ana María, et al.
Publicado: (2014)

Thioredoxin Modulates Protein Arginine Deiminase 4 (PAD4)-Catalyzed Citrullination
por: Nagar, Mitesh, et al.
Publicado: (2019)

Active site center redesign increases protein stability preserving catalysis in thioredoxin
por: Romero, Maria Luisa, et al.
Publicado: (2022)

Gold(I) and Gold(III) N‐Heterocyclic Carbene Complexes as Antibacterial Agents and Inhibitors of Bacterial Thioredoxin Reductase
por: Büssing, Rolf, et al.
Publicado: (2021)

Combinatorial Effect of Dietary Oregano Extracts and 3,4,5-Trihydroxy Benzoic Acid on Growth Performance and Elimination of Coccidiosis in Broiler Chickens
por: Nawarathne, Shan Randima, et al.
Publicado: (2022)

Predicting progression to active tuberculosis: A rate-limiting step on the path to elimination
por: Lalvani, Ajit, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_fs24bdc8m2p6g59sidf5t6fh4q