Concentration‐QT modelling of the novel DHFR inhibitor P218 in healthy male volunteers

AIMS: Given the increasing emergence of drug resistance in Plasmodium, new antimalarials are urgently required. P218 is an aminopyridine that inhibits dihydrofolate reductase being developed as a malaria chemoprotective drug. Assessing the effect of new compounds on cardiac intervals is key during e...

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Detalles Bibliográficos
Autores principales: Täubel, Jӧrg, Lorch, Ulrike, Ferber, Georg, Spencer, Christopher S., Freier, Anne, Coates, Simon, El Gaaloul, Myriam, Donini, Cristina, Chughlay, Mohamed Farouk, Chalon, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292718/
https://www.ncbi.nlm.nih.gov/pubmed/34075612
http://dx.doi.org/10.1111/bcp.14933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292718/
https://www.ncbi.nlm.nih.gov/pubmed/34075612
http://dx.doi.org/10.1111/bcp.14933

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