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Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre‐symptomatic female but not male htau mice

AIMS: Irisin is a hormone cleaved from fibronectin type‐III domain‐containing protein 5 in response to exercise and may be therapeutic in Alzheimer's disease (AD). Irisin is shown to repair damage caused by midlife cardiometabolic risk factors for AD (i.e., diabetes mellitus; hypertension), pre...

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Detalles Bibliográficos
Autores principales: Bretland, Katie A., Lin, Li, Bretland, Kimberly M., Smith, Matthew A., Fleming, Sheila M., Dengler‐Crish, Christine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292848/
https://www.ncbi.nlm.nih.gov/pubmed/33768561
http://dx.doi.org/10.1111/nan.12711