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Accounting for Precision Uncertainty of Toxicity Testing: Methods to Define Borderline Ranges and Implications for Hazard Assessment of Chemicals

For hazard classifications of chemicals, continuous data from animal‐ or nonanimal testing methods are often dichotomized into binary positive/negative outcomes by defining classification thresholds (CT). Experimental data are, however, subject to biological and technical variability. Each test meth...

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Detalles Bibliográficos
Autores principales: Gabbert, Silke, Mathea, Miriam, Kolle, Susanne N., Landsiedel, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292900/
https://www.ncbi.nlm.nih.gov/pubmed/33300210
http://dx.doi.org/10.1111/risa.13648