Comparison between physiologically based pharmacokinetic and population pharmacokinetic modelling to select paediatric doses of gepotidacin in plague

AIMS: To develop physiologically based pharmacokinetic (PBPK) and population pharmacokinetic (PopPK) models to predict effective doses of gepotidacin in paediatrics for the treatment of pneumonic plague (Yersinia pestis). METHODS: A gepotidacin PBPK model was constructed using a population‐based abs...

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Detalles Bibliográficos
Autores principales: Nguyen, Dung, Shaik, Jafar Sadik, Tai, Guoying, Tiffany, Courtney, Perry, Caroline, Dumont, Etienne, Gardiner, David, Barth, Aline, Singh, Rajendra, Hossain, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Twice Neglected Series: Neglected Diseases in Neglected Populations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293063/
https://www.ncbi.nlm.nih.gov/pubmed/34289143
http://dx.doi.org/10.1111/bcp.14996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293063/
https://www.ncbi.nlm.nih.gov/pubmed/34289143
http://dx.doi.org/10.1111/bcp.14996

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