Structure-based discovery of orally efficient inhibitors via unique interactions with H-pocket of PDE8 for the treatment of vascular dementia

Our previous study demonstrated that phosphodiesterase 8 (PDE8) could work as a potential target for vascular dementia (VaD) using a chemical probe 3a. However, compound 3a is a chiral compound which was obtained by chiral resolution on HPLC, restricting its usage in clinic. Herein, a series of non-...

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Detalles Bibliográficos
Autores principales: Wu, Xu-Nian, Zhou, Qian, Huang, Ya-Dan, Xie, Xi, Li, Zhe, Wu, Yinuo, Luo, Hai-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293670/
https://www.ncbi.nlm.nih.gov/pubmed/35865094
http://dx.doi.org/10.1016/j.apsb.2022.02.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293670/
https://www.ncbi.nlm.nih.gov/pubmed/35865094
http://dx.doi.org/10.1016/j.apsb.2022.02.012

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